== Reaction == HMGCR converts HMG-CoA to mevalonic acid: ==Interactive pathway map== == Inhibitors == === Drugs === Drugs that inhibit HMG-CoA reductase, known collectively as HMG-CoA reductase inhibitors (or `statins`), are used to lower serum cholesterol as a means of reducing the risk for cardiovascular disease. These drugs include rosuvastat.....
Found on
http://en.wikipedia.org/wiki/HMG-CoA_reductase
(EC 1.1.1.34) Integral membrane protein (97 kD) of ER and peroxisomes that catalyses reaction between hydroxy-methyl-glutaryl-CoA and two molecules of NADPH to produce mevalonate, a key starting material for the synthesis of cholesterol and other sterols. Because the enzyme is rate-limiting in synthesis it has made a good target for cholesterol-lowering drugs.
...
Found on
http://www.encyclo.co.uk/visitor-contributions.php
[
n] - a liver enzyme that is responsible for producing cholesterol
Found on
http://www.webdictionary.co.uk/definition.php?query=HMG-CoA%20reductase
No exact match found.
